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Tuesday, February 18, 2020

The history of Penicillin

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In 18,Alexander Fleming was straightening up a pile of Petri dishes where he had been growing bacteria, but which had been piled in the sink. He opened each one and examined it before tossing it into the cleaning solution. One made him stop and say, Thats funny.


Some mould was growing on one of the dishes... not too unusual, but all around the mould, the staph bacteria had been killed... very unusual. He took a sample of the mould. He found that it was from the penicillium family, later known as Penicillium notatum. Fleming presented his findings in 1, but they raised little interest. He published a report on penicillin and its potential uses in the British Journal of Experimental Pathology.


Fleming worked with the mould for some time, but refining and growing it was a difficult process better suited to a chemist. The work was taken over by a team of chemists and mould specialists, but was cut short when several of them died or relocated. Fleming found that this mould could kill the germs of a number of diseases and called it Penicillin. People then later on read about Flemings work, Edward Florey then got his team of scientists together to work on penicillin, one of these scientists was Ernst Chain, he then started to work on the idea of penicillin in 18. Two years later Floreys team of scientists had solved all of the problems dealing with penicillin, they could now make pure penicillin for the public to use. But before they could let the public try the penicillin they used eight mice to experiment on, they gave the eight mice the germs and then penicillin to four of them, the penicillin seemed to cure the mice that it had been given to but the mice that were not given penicillin died unfortunately. To make sure that it was the penicillin that cured the mice they had to run a few more experiments. One of these experiments was used on a police man that was sick, four days after the penicillin had been taken the police man was as chirpy as a bird, but then the next day he had fallen ill again due to the fact that the scientists didnt have enough penicillin. So they decided to go to the drug industry so that the drug companies could help with their findings. The government decided to help with the discovery of penicillin and gave Floreys team a grant to help develop penicillin and make bigger quantities of the new cure. Florey then flew to Russia to spread of his new ideas


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